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Korean Medication Algorithm Project for Bipolar Disorder 2022, Fifth Revision: An Executive Summary
Young Sup Woo1, Won-Myong Bahk1, Jong-Hyun Jeong1
1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Summary
The revised Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP) offers updated treatment guidelines for bipolar disorder. New recommendations focus on pharmacotherapy for manic, depressive, and mixed episodes in adults and youth.
Area of Science:
- Psychiatry
- Pharmacology
- Clinical Medicine
Background:
- The Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP) has been periodically updated since 2002.
- The latest revision, KMAP-BP 2022, incorporates recent advancements in bipolar disorder treatment.
Purpose of the Study:
- To revise the KMAP-BP guidelines based on current scientific evidence and clinical consensus.
- To provide updated pharmacotherapy recommendations for various phases of bipolar disorder.
Main Methods:
- A consensus-based approach involving 87 Korean psychiatrists and 40 child and adolescent psychiatry experts.
- Questionnaires with 56 items for adults and 7 items for pediatric patients were utilized.
Main Results:
- First-line treatments for manic episodes include mood stabilizer (MS) or atypical antipsychotic (AAP) monotherapy, or a combination of MS and AAP.
- For depressive episodes, first-line options include combinations of MS and AAP, or AAP and lamotrigine (LMT), or monotherapy with MS, AAP, or LMT.
- Treatment for mixed features recommends MS and AAP combination or monotherapy, with AAP and LMT or MS and LMT as options for depressive mixed states.
Conclusions:
- The KMAP-BP 2022 reflects changes in Korean healthcare and society, alongside new pharmacotherapy evidence.
- These updated guidelines offer valuable information for clinicians managing bipolar disorder patients.
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