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Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I
Tsung-Hua Lu1, Shih-Hsien Lin1,2, Huai-Hsuan Tseng1,2
1Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Objective:
Bipolar disorder (BD) is characterized by the poor sleep quality. Whether the striatal dopamine transporter (DAT) availability is related to sleep quality among patients with BD is unclear.
Methods:
Fifty-three euthymic patients with BD (24 BD-I and 29 BD-II) and sixty-eight healthy controls were enrolled. The Chinese Version of the Pittsburgh Sleep Quality Index (PSQI) was used, and the availability of DAT was assessed by single-photon emission computed tomography (SPECT) using [99mTc] TRODAT-1.
Results:
The sleep disturbance component of the PSQI was significantly associated with the level of DAT availability among patients with BD.
Conclusion:
The striatal dopaminergic activity that contributes to resilience to adversity was associated with sleep pattern among patients with BD.
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