KCC2 overexpressed exosomes meditated spinal cord injury recovery in mice

Exosomes show great potential in treating diseases of the central nervous system including spinal cord injury (SCI), still better engineered exosomes have more advantages. In this study, we purified exosomes from K⁺-Cl^-co-transporter (KCC2) overexpressed bone marrow mesenchymal stem cells (Exo_KCC2), to investigate the effect of Exo_KCC2on neural differentiationin vitroand the repairing function of Exo_KCC2in SCI micein vivo. Compared to bone marrow mesenchymal stem cells (BMSC)-derived exosomes (Exo), Exo_KCC2could better promote neural stem cell differentiated into neurons, ameliorate the function recovery of SCI mice, and accelerate the neural regeneration at the lesion site. Altogether, engineered Exo_KCC2may prove to be an advantageous strategy for SCI treatment.