Related Experiment Video

Updated: Aug 24, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
07:56

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

Published on: January 10, 2025

703

Retraction

    Journal of Cellular Physiology
    |October 20, 2022
    PubMed

    Insights

    This study on nucleus pulposus cells has been retracted due to unverified experimental data and duplicated images. The findings regarding IGFBP3 gene silencing and the ERK/MAPK pathway are considered invalid.

    Area of Science:

    • Cell Biology
    • Molecular Biology
    • Biochemistry

    Context:

    • The study investigated the role of Insulin-like Growth Factor Binding Protein 3 (IGFBP3) gene silencing.
    • Focus was on the Extracellular signal-Regulated Kinase/Mitogen-Activated Protein Kinase (ERK/MAPK) signaling pathway.
    • Research involved nucleus pulposus cells from rats.

    Purpose:

    • To examine the effects of IGFBP3 gene silencing on cell proliferation, apoptosis, autophagy, and senescence.
    • To understand the impact on the ERK/MAPK signaling pathway in rat nucleus pulposus cells.

    Summary:

    • The article "Effects of IGFBP3 gene silencing mediated inhibition of ERK/MAPK signaling pathway on proliferation, apoptosis, autophagy, and cell senescence in rats nucleus pulposus cells" has been retracted.
    • Retraction was based on the authors' inability to verify experimental data and the discovery of duplicated image elements.
    • The journal editors deemed the study's conclusions invalid due to these issues.

    Impact:

    • The retraction invalidates any conclusions drawn from the original publication.
    • This highlights the importance of data integrity and verification in scientific publishing.
    • Researchers should be aware that the findings related to IGFBP3, ERK/MAPK signaling, and nucleus pulposus cell behavior in this specific study are not scientifically supported.

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