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Related Experiment Videos

Increased thromboplastic potential in diabetes: a multifactorial phenomenon.

M M Landgraf-Leurs, T Ladik, B Smolka

    Klinische Wochenschrift
    |July 1, 1987
    PubMed
    Summary

    Diabetic patients exhibit heightened platelet aggregation and elevated coagulation factors, even in early stages. These changes indicate an increased risk of blood clots (hemostatic diathesis) in diabetes.

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    Area of Science:

    • Biochemistry
    • Hematology
    • Endocrinology

    Background:

    • Diabetes mellitus is associated with an increased risk of thrombotic events.
    • Understanding the hemostatic changes in diabetes is crucial for managing complications.

    Purpose of the Study:

    • To investigate coagulation parameters, platelet aggregation, and thromboxane production in diabetic patients.
    • To compare these parameters between diabetic patients with and without late complications and healthy controls.

    Main Methods:

    • Measurement of coagulation parameters, platelet aggregation (spontaneous and induced), and thromboxane B2 production.
    • Analysis of metabolic parameters including serum glucose, glycosylated hemoglobin, and glycosylated albumin.
    • Comparison between 31 diabetic patients (12 without, 19 with complications) and 14 healthy controls.

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    Main Results:

    • Diabetic patients showed increased spontaneous and induced platelet aggregation.
    • Elevated levels of fibrinogen, factor VIII related antigen, C1-esterase inhibitor, and antithrombin III were observed in patients with complications compared to controls.
    • Fibrinogen, C1-esterase inhibitor, and factor VIII related antigen were already elevated in diabetic patients without clinical complications.
    • No significant correlations were found between glycemic control and coagulation/aggregation parameters.

    Conclusions:

    • Early alterations in the thrombostatic process occur in diabetes, leading to an increased hemostatic diathesis.
    • Platelet hyperreactivity and elevated procoagulant factors contribute to the thrombotic risk in diabetes.
    • These hemostatic changes are present even before the manifestation of clinical complications.