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Mo154 Synergistically Enhanced Antibiofilm and Antibacterial Effects of Spermine via Coassembly

Yu Wang1, Xueping Kong1, Fei Li1

  • 1State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, No. 2699 Qianjin Street, Changchun 130012, P. R. China.

ACS Applied Bio Materials
|October 20, 2022
PubMed

Insights

A novel molybdenum-based assembly with spermine shows potent antibiofilm and bactericidal effects. This hybrid material enhances near-infrared photothermal therapy for combating resistant bacterial biofilms.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Antibiotic overuse drives biofilm formation, leading to treatment failure and global health risks.
  • Developing novel antibiofilm agents is crucial for effective infection control.
  • Biofilms pose significant challenges due to their inherent resistance to conventional therapies.

Purpose of the Study:

  • To create and evaluate a novel hybrid assembly for antibiofilm and bactericidal applications.
  • To investigate the photothermal properties of the assembly for enhanced therapeutic outcomes.
  • To improve the delivery and efficacy of antimicrobial agents against biofilms.

Main Methods:

  • Rational construction of a hybrid assembly using spermine (Spm) and molybdenum polyoxometalate clusters (Mo154).
  • Characterization of the assembly's aggregation and near-infrared (NIR) light absorption properties.
  • Assessment of the assembly's antibiofilm and bactericidal efficacy, including enhanced cellular uptake.

Main Results:

  • The Mo154/Spm assembly formed large aggregates, enhancing 808 nm light absorption for photothermal transition (PTT).
  • Spermine significantly improved Mo154 uptake by both biofilms and bacteria.
  • The hybrid assembly demonstrated potent antibiofilm and bactericidal effects, outperforming individual components.

Conclusions:

  • The Mo154/Spm assembly is an effective agent against bacterial biofilms and planktonic bacteria.
  • NIR-triggered photothermal therapy combined with enhanced cellular uptake offers a promising strategy for biofilm eradication.
  • This study provides a blueprint for designing advanced hybrid materials for combating antimicrobial resistance.
Keywords:
antibacterialantibiofilmphotothermal transitionpolyoxometalate assemblyspermine

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