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Assessment of Mouse Judgment Bias through an Olfactory Digging Task

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Assessing complex odor discrimination in mice using a novel instrumental patterning task.

Tanya A Gupta¹, Carter W Daniels¹, Jorge I Espinoza¹

¹Department of Psychology, Arizona State University.

Journal of Experimental Psychology. Animal Learning and Cognition

|October 20, 2022

Summary

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Mice exhibit interference when learning to distinguish individual odors from compound odor presentations. This instrumental negative patterning task reveals challenges in stimulus representation and associative learning mechanisms.

Area of Science:

Cognitive neuroscience
Animal behavior
Neuroscience

Background:

Negative patterning tasks are crucial for understanding how stimulus representations are acquired.
Discriminating single stimuli from compounds challenges simple associative learning theories.

Purpose of the Study:

To investigate how mice learn part-whole discrimination in olfactory stimuli using a novel instrumental methodology.
To examine the conditions influencing this discrimination learning in mice.

Main Methods:

Two experiments utilized an instrumental conditioning paradigm with odor mixtures.
Reinforcement was contingent on distinct responses to individual odors versus compound odor presentations.
C57BL/6 mice and wild-type APP/PS1 mice were used.

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Related Experiment Videos

Last Updated: Aug 24, 2025

Assessment of Mouse Judgment Bias through an Olfactory Digging Task

Assessment of Mouse Judgment Bias through an Olfactory Digging Task

Published on: March 4, 2022

Simple and Computer-assisted Olfactory Testing for Mice

Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

An Objective and Reproducible Test of Olfactory Learning and Discrimination in Mice

An Objective and Reproducible Test of Olfactory Learning and Discrimination in Mice

Published on: March 22, 2018

Main Results:

Experiment 1 demonstrated mutual interference in learning individual odor responses versus compound odor responses in C57BL/6 mice.
Experiment 2 replicated this interference in APP/PS1 mice, showing it to be stimulus-specific.
The findings indicate challenges in stimulus representation and associative learning.

Conclusions:

The instrumental negative patterning task complements Pavlovian tasks in studying associative learning.
This methodology raises new questions regarding the representation of complex stimuli.
The study provides insights into the mechanisms of stimulus discrimination in mice.