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The relationship between altered degree centrality and cognitive function in mild subcortical stroke: A resting-state
Yan Min1, Chang Liu2, Lijun Zuo1
1Department of Neurology, Beijing TianTan Hospital, Capital Medical University, Beijing, China.
Brain Research
|October 20, 2022
Summary
Patients with post-stroke cognitive impairment (PSCI) show altered brain connectivity. Increased degree centrality (DC) in the right parahippocampal gyrus correlates with poorer cognitive function, suggesting brain reorganization after stroke.
Area of Science:
- Neuroscience
- Cognitive Science
- Medical Imaging
Background:
- Post-stroke cognitive impairment (PSCI) is common, but its neurobiological mechanisms are not fully understood.
- Changes in brain functional connectivity (FC) are frequently observed in PSCI patients.
- Investigating intrinsic brain dysconnectivity patterns is crucial for understanding PSCI.
Purpose of the Study:
- To investigate the intrinsic dysconnectivity pattern in PSCI using degree centrality (DC) analysis.
- To explore the relationship between altered brain functional connectivity and cognitive function in stroke patients.
- To identify specific brain regions and connectivity changes associated with cognitive impairment after stroke.
Main Methods:
- Resting-state functional magnetic resonance imaging (rs-fMRI) was used to scan patients with PSCI (n=20), stroke without cognitive impairment (NPSCI, n=15), and healthy controls (HC, n=29).
- Degree centrality (DC) values were calculated to identify differences in functional connectivity (FC) among the three groups.
- The correlation between abnormal DC values and various cognitive function test scores was examined.
Main Results:
- Both PSCI and NPSCI groups exhibited significantly higher DC values in the right parahippocampal gyrus (PhG) compared to HC (p<0.05).
- DC values in the right PhG showed a significant negative correlation with scores on the MoCA, AVLT, RCFT-DR, SDMT, BNT, and AFT.
- Conversely, DC values in the PhG were positively correlated with TMT-A and TMT-B scores.
Conclusions:
- Mild subcortical stroke is associated with increased DC values in the right parahippocampal gyrus.
- The negative correlation between PhG DC values and cognitive function suggests a potential brain node reorganization mechanism in PSCI.
- These findings highlight the role of altered functional connectivity in the right PhG in the development of cognitive impairment post-stroke.
