Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome-wide association and population-tailored polygenic risk for Parkinson's disease in Taiwan.

NPJ Parkinson's disease·2026
Same author

Self-Controlled Feedback on Motor Learning and Neuroplastic Changes in People With Parkinson Disease.

Journal of neurologic physical therapy : JNPT·2026
Same author

Pharmacodynamics, Efficacy, and Safety of Intraputaminal Eladocagene Exuparvovec Administered to Pediatric Patients With Aromatic L-Amino Acid Decarboxylase Deficiency Using an MR-Compatible Cannula: 48 Weeks of Follow-Up.

Journal of inherited metabolic disease·2026
Same author

Parkinson's disease in transition: Genetics, biomarkers, and emerging therapeutics.

Journal of the Formosan Medical Association = Taiwan yi zhi·2025
Same author

Prevalence of NOTCH2NLC and FMR1 Repeat Expansions in Atypical Parkinsonism Compared to Asymptomatic Elderly Individuals.

Movement disorders : official journal of the Movement Disorder Society·2025
Same author

Real-Time Gas Identification at Room Temperature Using UV-Modulated Sb-Doped SnO<sub>2</sub> Sensors via Machine Learning.

ACS sensors·2025

Related Experiment Video

Updated: Aug 24, 2025

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

9.0K

Cerebellar deep brain stimulation for movement disorders.

Chun-Hwei Tai1, Sheng-Hong Tseng2

  • 1Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.

Neurobiology of Disease
|October 20, 2022
PubMed
Summary

Cerebellar deep brain stimulation (DBS) shows promise for movement disorders unresponsive to conventional targets. This review explores cerebellar DBS as a novel therapeutic approach for conditions like fixed dystonia and ataxia.

Keywords:
CerebellumDeep brain stimulationMovement disordersPathophysiology

More Related Videos

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

11.0K
A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test
07:14

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

Published on: May 31, 2016

14.8K

Related Experiment Videos

Last Updated: Aug 24, 2025

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

9.0K
Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

11.0K
A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test
07:14

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

Published on: May 31, 2016

14.8K

Area of Science:

  • Neuroscience
  • Neurosurgery
  • Movement Disorders

Background:

  • Conventional deep brain stimulation (DBS) targets basal ganglia and thalamus for movement disorders like Parkinson's disease.
  • Certain movement disorders, including fixed dystonia, ataxia, and freezing of gait, show limited response to current DBS therapies.
  • The cerebellum plays a crucial role in motor control and has emerged as a potential target for neuromodulation.

Purpose of the Study:

  • To review recent clinical data on cerebellar deep brain stimulation (DBS) for movement disorders.
  • To synthesize current understanding of cerebellar pathophysiology in movement disorders.
  • To discuss the potential mechanisms of action for cerebellar DBS.

Main Methods:

  • Review of recent clinical human subject studies reporting cerebellar DBS.
  • Analysis of indications, surgical targets, programming, and outcomes of cerebellar DBS.
  • Synthesis of existing pathophysiological research on the cerebellum and movement disorders.

Main Results:

  • Clinical studies suggest that patients with movement disorders refractory to conventional DBS may benefit from cerebellar DBS.
  • Deep cerebellar structures like the dentate nucleus and superior cerebellar peduncle are identified as potential targets.
  • Pioneering studies provide valuable insights into the clinical application and efficacy of cerebellar DBS.

Conclusions:

  • Cerebellar DBS represents a promising alternative or adjunctive therapy for specific movement disorders.
  • Further research into cerebellar targets and mechanisms is essential for comprehensive movement disorder treatment.
  • Exploring novel DBS targets in the cerebellum can expand therapeutic options beyond traditional basal ganglia approaches.