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Updated: Oct 1, 2026

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids
Published on: June 28, 2019
Abstract:
Treating racemic gossypol with chiral amine (S)-1-methylphenethyl amine gave the expected pair of diastereomeric amino condensates in which the binaphthyl nuclei racemized during further treatment. Acetylation was applied to avoid the change. On acetylation, 7 products were separated. Their structures were assigned based upon their spectroscopic data. After hydrolysis they gave optically active (+)- and (-)-gossypol correspondingly. A simple and practical method of quick separation of the diastereomers was also discussed.
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