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Unified Airway Disease: Medical Management
Eamon Shamil1, Claire Hopkins2
1Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom; ENT Department, Guy's Hospital, Great Maze Pond, London SE1 9RT, United Kingdom.
Abstract:
Concurrent chronic rhinosinusitis with nasal polyps (CRSwNP) in the upper airway, and asthma in the lower airway, often have a shared underlying pathophysiology, namely type 2 inflammation; hence, the term "unified airway disease." The combination of CRSwNP and asthma is associated with uncontrolled disease. The range of treatment of CRSwNP includes intranasal corticosteroids, nasal saline irrigation, oral corticosteroids, antibiotics, and biologics. A combined clinical algorithm for the management of the upper and lower airways in type 2 inflammation will be beneficial, especially for patients with uncontrolled disease who may benefit from biologics.
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