Related Experiment Video

Updated: Aug 24, 2025

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.7K

Remnant cholesterol levels are associated with severity and death in COVID-19 patients

Bibiana Fabre1,2, Nahuel Fernandez Machulsky1,2, Carolina Olano1,2

  • 1Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Cátedra de Bioquímica Clínica I, Junín 956 (C1113AAD), Buenos Aires, Argentina.

Scientific Reports
|October 20, 2022
PubMed

Insights

High remnant lipoprotein (RLP)-cholesterol levels are linked to severe COVID-19 outcomes and death. These findings highlight lipid metabolic disorders in patients with coronavirus disease-19 (COVID-19).

Area of Science:

  • Cardiovascular Research
  • Metabolic Disorders
  • Infectious Diseases

Background:

  • Patients with severe Coronavirus disease-19 (COVID-19) often have comorbidities like cardiovascular disease, hypertension, and type-2 diabetes mellitus.
  • These conditions share metabolic alterations, including insulin resistance (IR) and dyslipidemia.
  • Lipid-lipoprotein profiles are crucial in understanding disease severity and outcomes.

Purpose of the Study:

  • To evaluate the association between lipid-lipoprotein profile components, specifically remnant lipoprotein (RLP)-cholesterol, and COVID-19 severity.
  • To analyze the relationship between these lipid markers and mortality in hospitalized COVID-19 patients.
  • To identify lipid profiles indicative of metabolic disorders and insulin resistance in COVID-19.

Main Methods:

  • Studied 193 hospitalized COVID-19 patients and 200 controls.
  • Assessed lipoprotein profile, glucose, and procalcitonin levels.
  • Utilized binary logistic regression to identify predictors of death.

Main Results:

  • COVID-19 patients exhibited higher glucose, triglyceride (TG), TG/HDL-cholesterol, and RLP-cholesterol levels, alongside lower total, LDL, HDL, and non-HDL-cholesterol.
  • Age, non-HDL-cholesterol, and RLP-cholesterol were associated with mortality.
  • Worsening COVID-19 severity correlated with decreased cholesterol fractions but increased RLP-cholesterol and TG/HDL-cholesterol.

Conclusions:

  • Lower cholesterol fractions, except RLP-cholesterol and TG/HDL-cholesterol index, are linked to COVID-19 presence and severity.
  • Altered lipid profiles suggest metabolic disorders and insulin resistance in COVID-19 patients.
  • RLP-cholesterol levels are a significant predictor of COVID-19 severity and mortality.

More Related Videos

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.4K
Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans11:07

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Published on: December 19, 2014

12.8K

Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
269
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
643
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
31
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
923
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
797
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
25