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LITTing up Gliomas-Is the Future Bright?
Philip J O'Halloran1,2,3, Jack Henry4, Michael Amoo4
1Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Ontario, Canada.
World Neurosurgery: X
|October 21, 2022
Summary
Laser interstitial thermal therapy (LITT) shows potential for glioma treatment, with a pooled overall survival of 13.58 months and progression-free survival of 4.96 months. Complications occurred in 24% of patients.
Area of Science:
- Neurosurgery
- Oncology
- Medical Technology
Background:
- Laser interstitial thermal therapy (LITT) is a promising treatment for intracranial pathologies.
- Limited literature exists on LITT's efficacy for treating gliomas.
Purpose of the Study:
- To evaluate the efficacy of LITT in glioma treatment.
- To assess survival outcomes and complication rates associated with LITT for gliomas.
Main Methods:
- A systematic review and meta-analysis of studies published until March 19, 2021.
- Searched MEDLINE, EMBASE, Scopus, and Web of Science for LITT glioma treatment studies.
- Analyzed progression-free survival (PFS), overall survival (OS), and complication rates.
Main Results:
- 17 studies with 401 patients and 408 gliomas were included.
- Pooled mean OS was 13.58 months; pooled mean PFS was 4.96 months.
- Complications occurred in 24% of patients, with 11% being transient deficits.
Conclusions:
- LITT is increasingly used for deep-seated gliomas in patients with poor performance status.
- Further research is needed to confirm LITT's clinical effectiveness and survival benefits compared to standard treatments for gliomas.
