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Related Concept Videos

Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

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Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
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IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
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Aortic Regurgitation I: Introduction01:15

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IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
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Related Experiment Video

Updated: Aug 24, 2025

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Transcatheter aortic valve replacement in the developing world: Lessons learnt and its implications for practice.

Rajat Datta1, Prashant Bharadwaj2, Naveen Aggarwal3

  • 1Director General Armed Forces Medical Services, O/o DGAFMS, Defence Offices Complex, A Block, Africa Avenue, New Delhi, India.

Medical Journal, Armed Forces India
|October 21, 2022
PubMed
Summary

Transcatheter aortic valve replacement (TAVR) is effective for Indian patients with severe aortic stenosis and high surgical risk. This study shows good outcomes, even for those with bicuspid aortic valves.

Keywords:
Armed Forces experienceLessons learntTranscatheter aortic valve replacement

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Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Cardiac Surgery

Background:

  • Transcatheter aortic valve replacement (TAVR) is a recognized treatment for symptomatic severe calcific aortic stenosis in patients with intermediate to high surgical risk.
  • This study presents data from 84 such patients who underwent TAVR at two Indian Armed Forces cardiac centers.

Purpose of the Study:

  • To evaluate the effectiveness and outcomes of TAVR in a cohort of intermediate and high-risk Indian patients with severe aortic stenosis.
  • To assess procedural success, complications, and mortality rates at six months post-TAVR.

Main Methods:

  • A retrospective analysis of 84 patients who underwent TAVR between January 2017 and June 2021.
  • Procedures were primarily performed in the cardiac catheterization lab via a percutaneous transfemoral approach under conscious sedation.
  • Echocardiographic parameters were assessed at six months post-procedure.

Main Results:

  • The mean age of the 84 patients was 71.5 ± 8.4 years, with a Mean STS score of 6.34 ± 2.08.
  • Procedural success was high at 97.6%, with low rates of procedural mortality (2.3%), permanent pacemaker implantation (4.9%), and ischemic stroke (1.1%).
  • No cases of severe paravalvular leak were reported, and all-cause mortality at six months was 9.5%.

Conclusions:

  • TAVR is an effective treatment for intermediate and high-risk Indian patients suffering from severe aortic stenosis.
  • Patients with bicuspid aortic valves or prior bioprosthetic valves demonstrated favorable outcomes following TAVR.