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The pro-inflammatory factors contribute to the EEG microstate abnormalities in patients with major depressive

Ya-Nan Zhao1, Jia-Kai He1, Yu Wang1

  • 1Department of Physiology, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.

Brain, Behavior, & Immunity - Health
|October 21, 2022
PubMed

Insights

Pro-inflammatory factors are linked to brain network changes in major depressive disorder (MDD). These factors disrupt specific electroencephalogram (EEG) microstates, particularly microstate D, offering insights into MDD pathophysiology.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Immunology

Background:

  • Major depressive disorder (MDD) pathogenesis may involve pro-inflammatory factors affecting functional brain networks.
  • Electroencephalogram (EEG) microstates are indicators of brain network function, but their link to inflammation in MDD is unclear.

Purpose of the Study:

  • To investigate the relationship between serum pro-inflammatory factors and EEG microstate abnormalities in patients with MDD.
  • To explore how inflammation influences brain network dynamics in MDD.

Main Methods:

  • Compared EEG microstate characteristics (duration, occurrence, coverage) in 24 MDD patients and 24 healthy controls (HC).
  • Assessed serum levels of interleukin-2 (IL-2), tumor necrosis factor-α (TNF-α), and hs-C-reactive protein (CRP).
  • Utilized k-means clustering to identify and analyze four distinct EEG microstates.

Main Results:

  • MDD patients exhibited altered microstate patterns, including reduced duration, occurrence, and coverage of microstate B and D, and increased duration of microstate A and C compared to HC.
  • MDD group showed significantly higher levels of IL-2, TNF-α, and hs-CRP.
  • Duration, occurrence, and coverage of microstate D were negatively correlated with pro-inflammatory factor levels (IL-2, TNF-α, hs-CRP).

Conclusions:

  • Serum pro-inflammatory factors are associated with and likely induce abnormalities in EEG microstate D in MDD patients.
  • Findings suggest that inflammation contributes to EEG microstate alterations, providing a deeper understanding of MDD pathophysiology.
Keywords:
EEG microstatesFunctional brain networksMajor depressive disorderPro-inflammatory factors

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