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The relationship between vertebrobasilar artery calcification and intracranial atherosclerosis-related occlusion in

Nannan Han1,2, Gejuan Zhang1, Shiyao Yang3

  • 1Department of Neurology, Xi'an No. 3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, China.

Frontiers in Neurology
|October 21, 2022
PubMed

Insights

Vertebrobasilar artery calcification (VBAC) is an independent predictor of intracranial atherosclerosis-related occlusion (ICAS-O) in patients undergoing thrombectomy. Identifying VBAC can help predict ICAS-O, aiding surgical planning for acute ischemic stroke.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Radiology

Background:

  • Distinguishing intracranial atherosclerosis-related occlusion (ICAS-O) from non-ICAS-O is crucial for surgical planning before thrombectomy.
  • Vertebrobasilar artery calcification (VBAC) is a potential imaging marker for ICAS-O.

Purpose of the Study:

  • To investigate the association between VBAC and ICAS-O in patients with acute ischemic stroke undergoing thrombectomy.
  • To determine if VBAC can predict ICAS-O.

Main Methods:

  • A prospective, single-center study enrolled 314 patients undergoing thrombectomy between October 2017 and October 2021.
  • VBAC was assessed using pre-thrombectomy non-contrast computed tomography (NCCT) scans.
  • Binary logistic regression was used to analyze the association between VBAC and ICAS-O.

Main Results:

  • VBAC was detected in 36% of patients and was independently associated with ICAS-O (adjusted odds ratio, 6.16).
  • Age, hypertension, and diabetes were associated with VBAC.
  • Patients with VBAC and without atrial fibrillation showed a higher prevalence of ICAS-O.

Conclusions:

  • VBAC is an independent risk factor for ICAS-O in patients undergoing thrombectomy.
  • The presence of VBAC, particularly in patients without atrial fibrillation, is a significant indicator for ICAS-O.
Abstract

Keywords:
acute ischemic strokeintracranial atherosclerosis-related occlusionlarge vessel occlusionthrombectomyvertebrobasilar artery calcification

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