Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

397
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
397

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exa-cel in Children with Transfusion-Dependent β-Thalassemia or Sickle Cell Disease.

The New England journal of medicine·2026
Same author

Hematology in times of crisis: Lessons learned and strategic priorities from the EHA-ASH Joint Workshop on Ukraine.

HemaSphere·2026
Same author

A Novel Approach to In Vivo EPR Spectroscopy for Repeatable Assessments of Oxygenation Levels in Tumors at Any Depth: Preliminary Feasibility Studies Utilizing a Multisite Oxygen Sensor Inside HDR Brachytherapy Needles.

Advances in experimental medicine and biology·2026
Same author

Letting Biology Validate the EPR Imaging of Tumor pO<sub>2</sub>.

Advances in experimental medicine and biology·2026
Same author

Enhanced confocal microscopy with physics-guided autoencoders via synthetic noise modeling.

Scientific reports·2026
Same author

Beyond body weight: investigating the impact of body surface area on graft CD34+ cell dosing: a single-center experience.

Cytotherapy·2025

Related Experiment Video

Updated: Aug 24, 2025

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
08:25

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

15.4K

Knowledge-based planning for multi-isocenter VMAT total marrow irradiation.

Kang-Hyun Ahn1,2, Damiano Rondelli3, Matthew Koshy1,2

  • 1Department of Radiation Oncology, University of Illinois, Chicago, IL, United States.

Frontiers in Oncology
|October 21, 2022
PubMed
Summary
This summary is machine-generated.

Knowledge-based planning (KBP) for total marrow irradiation (TMI) significantly reduces planning time and improves dosimetric quality. This advanced VMAT-TMI approach streamlines complex treatments, making them more accessible.

Keywords:
RapidPlanTMIVMATknowledge-based planningradiotherapytotal marrow irradiation

More Related Videos

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

14.4K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.5K

Related Experiment Videos

Last Updated: Aug 24, 2025

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
08:25

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

15.4K
Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

14.4K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.5K

Area of Science:

  • Radiation Oncology
  • Medical Physics
  • Radiotherapy Planning

Background:

  • Total marrow irradiation (TMI) presents significant challenges in treatment planning and delivery due to large target volumes.
  • Volumetric modulated arc therapy (VMAT) reduces delivery time but planning complexity remains, especially with multiple isocenters and arcs.

Purpose of the Study:

  • To develop and evaluate a knowledge-based planning (KBP) model for VMAT-TMI to address clinical challenges in planning and delivery.
  • To improve the efficiency and quality of VMAT-TMI by leveraging a KBP approach.

Main Methods:

  • A KBP model was trained using data from 51 patients and validated on 22 patients, employing a 3-isocenter technique for head and neck, chest, and pelvis sub-volumes.
  • A base-dose plan strategy was used for chest, head and neck, and pelvis plans to minimize dose hot spots at junctions, with additional plans optimized without base-dose for model training.

Main Results:

  • KBP achieved clinical goals (95% PTV coverage) within one day, a significant reduction from the 4-6 days required previously.
  • Statistically significant reductions in mean dose to organs at risk (brain, lungs, oral cavity, lenses) were observed with KBP.
  • KBP substantially improved dose spillage, conformity index, and homogeneity index compared to conventional planning.

Conclusions:

  • Knowledge-based planning enhances dosimetric performance and ensures uniform quality in VMAT-TMI.
  • KBP reduces reliance on planner expertise and achieves a five-fold reduction in planning time, facilitating wider clinical adoption.