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Whole slide image data utilization informed by digital diagnosis patterns
Kimberly Ashman1, Huimin Zhuge1, Erin Shanley1
1Tulane University, Department of Biomedical Engineering, New Orleans, LA 70118, USA.
Journal of Pathology Informatics
|October 21, 2022
Summary
Digital pathology uses variable resolution images, reducing data storage needs. Pathologists can still make diagnoses with these smaller, lower-resolution whole slide images.
Area of Science:
- Digital Pathology
- Medical Imaging
- Pathology Informatics
Background:
- Digital pathology offers benefits but poses data storage challenges for whole slide images.
- Managing large digital whole slide image files requires significant infrastructure.
Purpose of the Study:
- To determine minimum pixel requirements for accurate pathology diagnosis.
- To analyze pathologist slide viewing patterns for diagnostic resolution needs.
Main Methods:
- Developed variable resolution images based on pathologist viewing patterns.
- Assessed diagnostic accuracy using reduced-resolution virtual slides.
- Included a second pathologist to validate diagnoses on variable resolution images.
Main Results:
- Pathologists rarely utilized full resolution, indicating potential for data reduction.
- Variable resolution images were significantly smaller than original whole slide images.
- Diagnoses were successfully rendered on reduced-resolution images by a pathologist.
Conclusions:
- Variable resolution imaging can substantially decrease data storage requirements for digital pathology.
- Further research needed on inter- and intra-pathologist variability in resolution needs.
