Related Experiment Video

Updated: Aug 24, 2025

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

69.1K

Association Between Triglyceride-Glucose Index and Risk of Metabolic Dysfunction-Associated Fatty Liver Disease: A

Ru Zhang1, Qing Guan1, Mengting Zhang1

  • 1School of Nursing, Nanjing Medical University, Nanjing, People's Republic of China.

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
|October 21, 2022
PubMed
Abstract

Insights

A high triglyceride-glucose (TyG) index is linked to an increased risk of developing metabolic dysfunction-associated fatty liver disease (MAFLD). This finding suggests the TyG index could aid in MAFLD prevention strategies.

Area of Science:

  • Metabolic health
  • Hepatology
  • Cardiovascular risk factors

Background:

  • Insulin resistance (IR) is a key factor in metabolic dysfunction-associated fatty liver disease (MAFLD) development.
  • The triglyceride-glucose (TyG) index is a readily available marker for IR.
  • The association between the TyG index and incident MAFLD requires further investigation.

Purpose of the Study:

  • To examine the relationship between baseline TyG index and the risk of developing MAFLD.
  • To assess the TyG index as a predictor for incident MAFLD in a Chinese cohort.

Main Methods:

  • A health check-up cohort of 2056 Chinese individuals was established.
  • The TyG index was calculated using fasting triglyceride and glucose levels: ln (fasting triglyceride [mg/dL]×fasting glucose [mg/dL]/2).
  • Cox proportional hazard models and restricted cubic spline analysis were employed to evaluate the longitudinal association.

Main Results:

  • Over a mean follow-up of 2.5 years, 12.8% of participants developed MAFLD, with incidence increasing across TyG index quartiles (Ptrend < 0.05).
  • A higher baseline TyG index independently predicted increased MAFLD risk (HR = 1.784, P < 0.001).
  • The highest TyG index quartile showed a twofold higher MAFLD risk compared to the lowest (95% CI = 1.377-2.992, P = 0.001). The relationship was linear in males and nonlinear in females.

Conclusions:

  • Elevated baseline TyG index is independently associated with a higher risk of incident MAFLD.
  • The TyG index may serve as a valuable tool for developing preventative strategies against MAFLD.
Keywords:
cohort studyinsulin resistancemetabolic dysfunction-associated fatty liver diseaserisktriglyceride-glucose index

More Related Videos

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis08:58

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis

Published on: March 11, 2017

16.1K
Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

348

Related Concept Videos

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
2.1K
Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
1.5K
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
585
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
653
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
269
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
643