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Pulmonary Epithelial-Myoepithelial Carcinoma
Lingru Chen1,2,3,4, Ying Fan1,2,3,4, Hongyang Lu1,2,3,4
1Zhejiang Key Laboratory of Diagnosis & Treatment Technology on Thoracic Oncology (Lung and Esophagus), Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou 310022, China.
Journal of Oncology
|October 21, 2022
Summary
Pulmonary epithelial-myoepithelial carcinoma (P-EMC) is a rare lung tumor. Diagnosis relies on pathology and immunohistochemistry, with surgery as the primary treatment.
Area of Science:
- Pulmonary pathology
- Oncology
- Rare lung tumors
Background:
- Pulmonary epithelial-myoepithelial carcinoma (P-EMC) is an extremely rare salivary gland-type lung tumor.
- It presents as a biphasic tumor with distinct epithelial and myoepithelial cell layers.
- Bronchial obstruction is a key clinical symptom, often leading to misdiagnosis due to similarity with non-small-cell lung cancer (NSCLC).
Purpose of the Study:
- To review the pathological and molecular characteristics of P-EMC.
- To outline diagnostic strategies, including immunohistochemistry.
- To discuss current treatment modalities and prognosis.
Main Methods:
- Review of existing literature on P-EMC.
- Analysis of pathological and immunohistochemical findings.
- Summary of clinical presentation, treatment outcomes, and prognosis.
Main Results:
- P-EMC diagnosis is confirmed by characteristic biphasic histology and immunohistochemistry (cytokeratin, S100, SMA).
- While generally low-grade, P-EMC can recur or metastasize.
- Surgical resection is the main treatment; chemotherapy and radiotherapy show limited efficacy.
Conclusions:
- Accurate diagnosis of P-EMC requires a combination of clinical, pathological, and immunohistochemical evaluation.
- Optimal treatment strategies are still under investigation, with surgery being the current standard.
- Further research into targeted and immunotherapies is warranted.
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