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Therapeutic effect of natural polyphenols against glioblastoma
Ozal Beylerli1, Aferin Beilerli2, Alina Shumadalova3
1Рeoples' Friendship University of Russia (RUDN University), Moscow, Russia.
Abstract:
Glioblastoma (GBM) is the most common and aggressive tumor of the central nervous system, which has a highly invasive growth pattern, which creates poor prospects for patient survival. Chemotherapy and tumor surgery are limited by anticancer drug resistance and tumor invasion. Evidence suggests that combinations of treatments may be more effective than single drugs alone. Natural polyphenolic compounds have potential as drugs for the treatment of glioblastoma and are considered as potential anticancer drugs. Although these beneficial effects are promising, the efficacy of natural polyphenolic compounds in GBM is limited by their bioavailability and blood-brain barrier permeability. Many of them have a significant effect on reducing the progression of glioblastoma through mechanisms such as reduced migration and cell invasion or chemosensitization. Various chemical formulations have been proposed to improve their pharmacological properties. This review summarizes natural polyphenolic compounds and their physiological effects in glioblastoma models by modulating signaling pathways involved in angiogenesis, apoptosis, chemoresistance, and cell invasion. Polyphenolic compounds are emerging as promising agents for combating the progression of glioblastoma. However, clinical trials are still needed to confirm the properties of these compounds in vitro and in vivo.
Insights
Natural polyphenolic compounds show promise in treating glioblastoma (GBM) by inhibiting tumor progression and enhancing chemotherapy. Further clinical trials are needed to confirm their efficacy and overcome bioavailability challenges for brain tumors.
Area of Science:
- Neuro-oncology
- Pharmacology
- Natural Products Chemistry
Background:
- Glioblastoma (GBM) is an aggressive brain tumor with poor survival rates, often resistant to standard treatments like chemotherapy and surgery.
- Tumor invasion and drug resistance significantly limit therapeutic outcomes in GBM patients.
- Natural polyphenolic compounds are being investigated for their potential anticancer properties against GBM.
Purpose of the Study:
- To review the physiological effects of natural polyphenolic compounds in glioblastoma models.
- To summarize their mechanisms of action, including modulation of signaling pathways.
- To highlight challenges and potential strategies for improving their efficacy in GBM treatment.
Main Methods:
- Literature review of studies on natural polyphenolic compounds and GBM.
- Analysis of *in vitro* and *in vivo* glioblastoma models.
- Summary of research on signaling pathways (angiogenesis, apoptosis, chemoresistance, invasion) affected by polyphenols.
Main Results:
- Polyphenolic compounds demonstrate potential in reducing GBM progression via anti-migration, anti-invasion, and chemosensitization mechanisms.
- These compounds modulate key signaling pathways crucial for tumor growth and survival.
- Challenges remain regarding bioavailability and blood-brain barrier permeability, necessitating formulation improvements.
Conclusions:
- Natural polyphenolic compounds are promising therapeutic agents for glioblastoma.
- Further research and clinical trials are essential to validate their efficacy and optimize delivery for brain tumors.
- Formulation strategies are crucial to enhance the pharmacological properties of these natural compounds for GBM treatment.
