Related Experiment Video
Updated: Aug 24, 2025

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
ONCOS-102: A Step Forward or Sideways?
Shoshana T Levi1,2, Genevieve M Boland1,2
1Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Abstract:
Treatment of anti-PD-1 refractory melanoma remains a challenge. Intratumoral injection of ONCOS-102, a chimeric oncolytic adenovirus expressing GMCSF, into anti-PD-1-resistant melanoma with administration of pembrolizumab was safe and effective. Response to therapy was associated with increased lymphocyte infiltration and expression of cytotoxicity and costimulatory genes. See related article by Shoushtari et al., p. 100.
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