Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

4.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
4.9K
Inflammation01:38

Inflammation

54.4K
Overview
54.4K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sodium alginate for wound healing applications: A review.

Polimery w medycynie·2026
Same author

Lab-on-a-tip platform with cotton matrices for colorimetric detection of carmine in lipsticks.

RSC advances·2026
Same author

Secoisolariciresinol diglucoside ameliorates muscarinic acetylcholine receptor mediated activation of NLRP3 inflammasome in cardiomyocytes.

Molecular biology reports·2026
Same author

Dapagliflozin confers protection against ferroptosis in cardiomyocyte via the inhibition of interferon-gamma pathway.

Molecular biology reports·2026
Same author

Role of polymeric nanocomposite for tissue engineering applications.

RSC advances·2026
Same author

Antiseptic chitosan acetate-chlorhexidine spray for wound cleaning.

Journal of materials science. Materials in medicine·2026

Related Experiment Video

Updated: Aug 24, 2025

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
05:50

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

1.3K

Double functionalized haemocompatible silver nanoparticles control cell inflammatory homeostasis.

Mamta Kumawat1, Harishkumar Madhyastha2, Mandeep Singh3

  • 1Amity Center for Nanobiotechnology and Nanomedicine (ACNN), Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, Rajasthan, India.

Plos One
|October 21, 2022
PubMed
Summary

Researchers developed novel silver nanoparticles conjugated with curcumin and functionalized with other molecules to combat inflammation. These nanoparticles effectively reduced pro-inflammatory cytokines, showing promise for biomedical applications in controlling inflammatory diseases.

More Related Videos

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
09:51

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

12.5K
Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization
08:13

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization

Published on: December 3, 2020

4.7K

Related Experiment Videos

Last Updated: Aug 24, 2025

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
05:50

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

1.3K
Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
09:51

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

12.5K
Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization
08:13

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization

Published on: December 3, 2020

4.7K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Immunology

Background:

  • Tissue inflammation, triggered by infection, trauma, or autoimmunity, causes pain and functional loss.
  • Nanotechnology offers promising strategies for inflammation control, with metal-based nanoparticles being particularly advantageous.
  • Silver nanoparticles (AgNPs) are attractive due to their synthesis ease, tunable properties, and surface modification capabilities.

Purpose of the Study:

  • To synthesize and characterize curcumin-conjugated silver nanoparticles (Cur-AgNPs).
  • To functionalize Cur-AgNPs with isoniazid (INH), tyrosine (Tyr), and quercetin (Qrc).
  • To evaluate the anti-inflammatory potential of these novel nanoparticles.

Main Methods:

  • Synthesis of curcumin-conjugated silver nanoparticles (Cur-AgNPs).
  • Surface functionalization of Cur-AgNPs with INH, Tyr, and Qrc to create Cur-AgINH, Cur-AgTyr, and Cur-AgQrc.
  • Assessment of radical scavenging capacity, hemocompatibility, and cytotoxicity against macrophages.
  • Measurement of pro-inflammatory cytokine secretion (IL-6, TNF-α, IL-1β) from LPS-stimulated macrophages.

Main Results:

  • The synthesized nanoparticles demonstrated radical scavenging capacity, hemocompatibility, and low cytotoxicity.
  • All functionalized nanoparticles effectively inhibited the secretion of key pro-inflammatory cytokines (IL-6, TNF-α, IL-1β) from LPS-stimulated macrophages.
  • Surface functionalization critically influenced nanoparticle efficacy in biomedical applications.

Conclusions:

  • Novel Cur-AgNPs functionalized with INH, Tyr, or Qrc exhibit significant anti-inflammatory properties.
  • These nanoparticles represent a promising nanomedicine approach for managing inflammatory conditions.
  • Tailoring the nanoparticle surface corona is crucial for enhancing their therapeutic efficacy.