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A versatile CRISPR/Cas12a-based biosensing platform coupled with a target-protected transcription strategy

Xinyue Kang1, Chao Lei1, Jingjing Shi1

  • 1Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an, 710119, Shaanxi Province, PR China.

Biosensors & Bioelectronics
|October 21, 2022
PubMed
Summary

This study introduces a CRISPR/Cas12a biosensing platform for sensitive biomolecule detection. The novel system uses target-induced protection and transcription amplification for enhanced signal generation in bioanalysis.

Keywords:
CRISPR/Cas12aExosomesTarget protectionTranscriptionmicroRNAs

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