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Hepatic assist device, using membrane plasma separator and dialyzer.

Z Yamazaki, N Inoue

    Medical Progress Through Technology
    |January 1, 1987
    PubMed
    Summary
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    This study introduces a novel hepatic assist device for acute liver failure. Plasma exchange using this device shows promise, improving survival rates and prolonging life in critical patients.

    Area of Science:

    • Hepatology
    • Biomedical Engineering
    • Critical Care Medicine

    Background:

    • Fulminant hepatic failure presents a critical medical challenge with limited treatment options.
    • Acute liver failure necessitates rapid and effective therapeutic interventions to improve patient outcomes.

    Purpose of the Study:

    • To evaluate the efficacy and safety of a novel hepatic assist device for plasma exchange in patients with acute liver failure.
    • To assess the impact of the hepatic assist device on survival rates and survival time in critical liver failure cases.

    Main Methods:

    • The hepatic assist device integrates a membrane plasma separator, blood/plasma pumps, hemodialyzer, and controller.
    • Daily plasma exchange procedure involving replacement of patient plasma with 5000 ml of donor plasma.

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  • Procedure conducted in the intensive care unit until patient recovery or confirmation of cerebral death.

    • Main Results:

    • Initial results indicate a 50% survival rate (5 out of 10 patients) in the cohort with fulminant hepatic failure.
    • The hepatic assist device facilitated plasma exchange, a procedure noted for its ease and safety.
    • Even in non-survivable cases, a prolongation of survival time was observed, suggesting a palliative benefit.

    Conclusions:

    • The developed hepatic assist device represents a promising approach for providing long-term hepatic support in acute liver failure.
    • Plasma exchange via this device offers a potentially life-saving intervention for patients with severe liver dysfunction.
    • The device's performance suggests it could become a valuable tool in managing critical liver failure cases.