Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Theophylline-induced changes in the mouse brainstem auditory evoked potential.

M W Church, D W Shucard

    Neurotoxicology and Teratology
    |January 1, 1987
    PubMed
    Summary

    Theophylline may cause slight, temporary hearing loss in mice, indicated by brainstem auditory evoked potential (BAEP) changes. This suggests potential ototoxic effects, especially for patients on chronic theophylline treatment.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cognitive and White Matter Tract Differences in MS and Diffuse Neuropsychiatric Systemic Lupus Erythematosus.

    AJNR. American journal of neuroradiology·2015
    Same author

    Brain serotonin determines maternal behavior and offspring survival.

    Genes, brain, and behavior·2014
    Same author

    Multimodal imaging in systemic lupus erythematosus patients with diffuse neuropsychiatric involvement.

    Lupus·2013
    Same author

    Repeated antenatal corticosteroid treatments adversely affect neural transmission time and auditory thresholds in laboratory rats.

    Neurotoxicology and teratology·2011
    Same author

    Excess omega-3 fatty acid consumption by mothers during pregnancy and lactation caused shorter life span and abnormal ABRs in old adult offspring.

    Neurotoxicology and teratology·2009
    Same author

    Abnormal neurological responses in young adult offspring caused by excess omega-3 fatty acid (fish oil) consumption by the mother during pregnancy and lactation.

    Neurotoxicology and teratology·2008

    Area of Science:

    • Neuroscience
    • Ototoxicology
    • Pharmacology

    Background:

    • Theophylline is a common analeptic drug with known therapeutic uses.
    • Concerns exist regarding its potential ototoxic and neurotoxic side effects.

    Purpose of the Study:

    • To investigate the acute effects of theophylline on auditory electrophysiology in mice.
    • To assess potential ototoxic and neurotoxic impacts of theophylline using BAEP.

    Main Methods:

    • Adult female C57BL/6 mice were administered intraperitoneal injections of theophylline (150 mg/kg) or saline.
    • Brainstem auditory evoked potential (BAEP) was used to evaluate auditory function.

    Main Results:

    • Theophylline induced a statistically significant, albeit slight, change in auditory function.

    Related Experiment Videos

  • BAEP findings suggested a temporary recruitment-type sensorineural deficit.
  • No evidence of neurotoxic effects was observed.

    • Conclusions:

    • Theophylline demonstrates potential ototoxic effects, manifesting as a temporary sensorineural deficit.
    • These findings warrant caution regarding chronic theophylline use in susceptible populations, including asthmatic patients and preterm neonates.