[Endotoxemia after surgery in digestive diseases].

Area of Science:

• Gastroenterology
• Surgical Oncology
• Critical Care Medicine

Context:

• Investigating postoperative endotoxin levels in patients with digestive diseases.
• Assessing complications related to endotoxemia in surgical patients.
• Comparing endotoxin levels in patients with and without liver cirrhosis or obstructive jaundice.

Purpose:

• To determine the relationship between digestive diseases (liver cirrhosis, obstructive jaundice) and postoperative endotoxin levels.
• To identify potential complications associated with endotoxemia in these patient groups.
• To explore the link between high endotoxin levels and the development of multiple organ failure (MOF).

Summary:

• Patients without liver cirrhosis or obstructive jaundice showed minimal postoperative endotoxin elevation.
• Patients with liver cirrhosis exhibited notable and persistent endotoxemia, especially after splenectomy and hepatectomy.
• Patients with obstructive jaundice also developed significant endotoxemia, with associated gastrointestinal bleeding and disseminated intravascular coagulation (DIC).

Impact:

• Highlights the increased risk of endotoxemia in patients with liver cirrhosis and obstructive jaundice undergoing surgery.
• Suggests a potential correlation between sustained high endotoxin levels and the development of multiple organ failure (MOF).
• Informs clinical management and risk assessment for surgical patients with underlying digestive diseases.