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Updated: Aug 24, 2025

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Bone marrow MR perfusion imaging and potential for tumor evaluation

James F Griffith1, R A van der Heijden2,3

  • 1Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, Hong Kong, Hong Kong. griffith@cuhk.edu.hk.

Skeletal Radiology
|October 21, 2022
PubMed

Insights

Bone perfusion imaging using MRI techniques can assess tumor activity and treatment response. These methods offer insights beyond standard MRI for evaluating bone conditions.

Area of Science:

  • Bone physiology
  • Medical imaging
  • Oncology

Background:

  • Bone perfusion is crucial for assessing bone health and disease.
  • Standard MRI provides anatomical information but limited functional data on bone perfusion.
  • Assessing tumor activity and treatment response in bone requires advanced imaging techniques.

Purpose of the Study:

  • To review the physiology of bone perfusion.
  • To outline measurement techniques for bone perfusion using MRI.
  • To highlight the potential of bone perfusion imaging in oncology.

Main Methods:

  • Review of physiological principles of bone perfusion.
  • Description of dynamic contrast-enhanced MRI (DCE-MRI) for bone perfusion assessment.
  • Explanation of intravoxel incoherent imaging (IVIM) for bone perfusion analysis.

Main Results:

  • Bone perfusion physiology can be elucidated through advanced MRI techniques.
  • DCE-MRI and IVIM are viable methods for quantifying bone perfusion.
  • Bone perfusion imaging shows promise in evaluating tumor burden and therapeutic efficacy.

Conclusions:

  • Bone perfusion imaging offers a functional assessment of bone tissue.
  • Advanced MRI techniques like DCE-MRI and IVIM enhance the evaluation of bone tumors.
  • Perfusion parameters derived from MRI can serve as biomarkers for treatment response in bone pathologies.
Keywords:
BoneDynamic contrast-enhanced MRIIntravoxel-incoherent imagingMRIPerfusionPhysiologyTumor

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