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Neurogenesis and Regeneration of Nervous Tissue01:15

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Neuronal desertification after a direct lightning strike: a case report.

Erik Roman-Pognuz1,2, Edoardo Moro3, Elisabetta Macchini4

  • 1Department of Surgical Medical and Health Sciences, University of Trieste, Trieste, Italy. romanpognuz.erik@gmail.com.

Journal of Medical Case Reports
|October 22, 2022
PubMed
Summary
This summary is machine-generated.

A severe lightning strike caused immediate cardiac arrest and profound brain injury, leading to death. Post-mortem examination revealed widespread neuronal loss, highlighting the devastating neurological effects of lightning trauma.

Keywords:
Brain injuryCardiac arrestHypoxic ischaemic brain injuryLightning strikeNeuronal desertification

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Area of Science:

  • Neurology
  • Traumatology
  • Forensic Pathology

Background:

  • Lightning strikes are rare but severe causes of injury.
  • Patients with lightning strike injuries admitted to ICUs often face high mortality and long-term neurological deficits.
  • Direct brain injury and cardiac arrest are common complications.

Observation:

  • A 50-year-old man experienced immediate cardiac arrest after a lightning strike.
  • Neurological assessment revealed severe brain injury, including loss of grey-white matter differentiation and absent somatosensory-evoked potentials.
  • Minimal cerebral electrical activity was recorded on EEG.

Findings:

  • The patient died on day 10 due to neurological injury.
  • Post-mortem examination showed a widespread loss of neurons.
  • A unique pattern of neuronal 'desertification' was observed microscopically.

Implications:

  • This case underscores the severe neurotoxic effects of lightning strikes.
  • The findings emphasize the need for specialized care for lightning strike survivors.
  • Understanding these patterns can aid in diagnosing and managing lightning-related brain injuries.