Causal relationships between mood instability and autoimmune diseases: A mendelian randomization analysis
Huahua Zhong1, Xiao Huan1, Kexin Jiao1
1Department of Neurology and Huashan Rare Disease Center, Huashan Hospital, Shanghai Medical College, Fudan University, National Center for Neurological Disorders, 12th Wulumuqi Zhong Road, Shanghai 200040, China.
Autoimmunity Reviews
|October 22, 2022
Summary
Mood instability is a modifiable risk factor for asthma, hypothyroidism, and systemic lupus erythematosus. This study used Mendelian randomization to investigate the causal link between this personality trait and autoimmune diseases.
Area of Science:
- Genetics and immunology
- Psychiatry and behavioral science
- Epidemiology
Background:
- The connection between mental health and autoimmune diseases is increasingly recognized.
- Causality between personality traits and autoimmune conditions remains under-explored.
Discussion:
- Mood instability demonstrated a genetic predisposition to asthma, hypothyroidism, and systemic lupus erythematosus.
- Findings were robust across various Mendelian randomization methods, ethnicities, and genders.
Key Insights:
- Mood instability is a significant risk factor for asthma, hypothyroidism, and systemic lupus erythematosus.
- Asthma showed predisposition in Finnish and mixed populations, and in females.
- Hypothyroidism showed predisposition in both genders.
Outlook:
- Mood instability represents a potentially modifiable target for autoimmune disease prevention.
- Further research can explore interventions targeting mood instability to mitigate autoimmune disease risk.
- Understanding these links can inform personalized medicine approaches in autoimmune disorders.
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