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Updated: Aug 24, 2025

Pancreatic Tissue Dissection to Isolate Viable Single Cells
Published on: May 26, 2023
The microbiota and aging microenvironment in pancreatic cancer: Cell origin and fate
Zhou Chen1, Zhengfeng Wang1, Yan Du2
1The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu Province, China; The First Hospital of Lanzhou University, Lanzhou, Gansu Province, China.
Abstract:
Cellular senescence is a state of growth arrest where nonproliferative cells accumulate over time in the aging microenvironment under multiple external factors. Senescent cells exert a double-edged sword effect in an autocrine or paracrine manner: physiologically, they contribute to tissue development, prevent the multiplication of damaged cells and contribute to tissue repair and tumor suppression while favoring the onset of age-related diseases, including tumors. The microbiota in human tissues is intricately linked to cellular senescence and is reportedly present in the tissues of various tumors (including pancreatic tumors), closely associated with tumorigenesis and progression. The microbiota can induce cells to undergo senescence, and their long-term effects can assist senescent cells in transforming and successfully escaping senescence, contributing to tumorigenesis and progression. Here, we focus on the correlation between the microbiota, cellular senescence, and pancreatic cancer to provide novel ideas for the study and therapy of pancreatic cancer.
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