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Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

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Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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Necrosis01:16

Necrosis

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
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Heart Failure Drugs: Inotropic Agents01:26

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Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
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Heart Failure I: Introduction01:27

Heart Failure I: Introduction

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Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Ferroptosis in heart failure.

Xinquan Yang1, Nicholas K Kawasaki2, Junxia Min1

  • 1The Fourth Affiliated Hospital, The First Affiliated Hospital, Institute of Translational Medicine, School of Public Health, Cancer Center, State Key Laboratory of Experimental Hematology, Zhejiang University School of Medicine, Hangzhou 310058, China.

Journal of Molecular and Cellular Cardiology
|October 23, 2022
PubMed
Summary
This summary is machine-generated.

Heart failure (HF) is a growing global health threat. This review explores how ferroptosis, a form of cell death, contributes to HF, offering insights into new therapeutic strategies.

Keywords:
FerroptosisGlutathione homeostasisHeart failureIron metabolismLipid metabolism

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Area of Science:

  • Biomedical Science
  • Cardiovascular Research
  • Cell Death Mechanisms

Background:

  • Heart failure (HF) presents complex pathobiology and pathophysiology, posing a significant global health challenge.
  • Ferroptosis, a distinct form of regulated cell death, is characterized by iron-dependent lipid peroxide accumulation.
  • Key regulatory pathways for ferroptosis include iron handling, redox homeostasis, and lipid metabolism.

Purpose of the Study:

  • To review the current understanding of the relationship between ferroptosis and heart failure.
  • To critically examine the progression of ferroptotic signals and their impact on cardiac remodeling in HF.
  • To identify ferroptosis as a potential target for novel therapeutic interventions in HF.

Main Methods:

  • Literature review of existing research on ferroptosis and heart failure.
  • Analysis of biological pathways regulating ferroptosis.
  • Examination of the role of ferroptosis in various HF-inducing conditions (e.g., myocardial infarction, ischemia-reperfusion).

Main Results:

  • Ferroptosis has been implicated in the pathogenesis of HF triggered by diverse stimuli.
  • Understanding ferroptosis mechanisms is crucial for developing targeted therapies.
  • Ferroptotic signals contribute to cardiac remodeling in the context of heart failure.

Conclusions:

  • Ferroptosis plays a significant role in the development and progression of heart failure.
  • Targeting ferroptosis pathways offers a promising avenue for novel therapeutic strategies in HF.
  • Further research into ferroptosis-related medicine is essential for advancing HF treatment.