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Updated: Aug 24, 2025

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
Changes in epigenetic information during the occurrence and development of gastric cancer
Niannian Li1, Gang Meng2, Chunjuan Yang3
1The Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Nankai University, Tianjin 300071, China; School of Life Sciences, Nankai University, Tianjin 300071, China; Central Laboratory of the First Affiliated Hospital, Weifang Medical University, Weifang 261000, China.
Abstract:
Gastric cancer is one of the most common malignant tumors of the digestive tract, with a high degree of malignancy and poor prognosis. With advancements in disease research, the role of epigenetic changes in its pathogenesis has become a research focus. The known epigenetic changes mainly include DNA methylation, histone modification, and regulation of chromatin structure. This article details the effects of these changes that would result in gastric cancer. Using next-generation sequencing methods and bioinformatics analysis, we can determine the epigenetic changes in abnormal tissues of the digestive tract that facilitate the early diagnosis and treatment of gastric cancer patients. In this article, we summarize how epigenetic changes determine gastric cancer and the new technologies used in research on cancer to benefit gastric cancer patients.
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