pH and its applications in targeted drug delivery
Sadikalmahdi Abdella1, Fatima Abid2, Souha H Youssef2
1Centre for Pharmaceutical Innovation (CPI), University of South Australia, Adelaide, SA 5000, Australia; Department of Pharmacology and Clinical Pharmacy, College of Health Sciences, Addis Ababa University, Zambia St, Addis Ababa, Ethiopia.
Drug Discovery Today
|October 23, 2022
Summary
Physiologic pH influences tissue function and enables smart drug delivery systems (DDS). These pH-sensitive DDS show promise for treating diseases like cancer and H. pylori infection.
Area of Science:
- Biomedical Engineering
- Pharmaceutics
- Drug Delivery Systems
Background:
- Physiologic pH is crucial for normal tissue function and exhibits regional variations within the body.
- The pH variability across different body sites has been leveraged for targeted drug delivery.
- Altered pH levels can serve as diagnostic biomarkers for certain conditions.
Purpose of the Study:
- To comprehensively review the development of pH-sensitive drug delivery systems (DDS).
- To explore the diverse applications of these advanced DDS in various medical fields.
- To highlight recent innovations and future directions in pH-responsive drug delivery technology.
Main Methods:
- Review of existing literature on pH-sensitive DDS.
- Analysis of successful applications in treating specific diseases.
- Examination of diagnostic potential based on pH biomarkers.
Main Results:
- pH-sensitive DDS have shown significant promise in treating challenging diseases such as cancer and H. pylori infections.
- These systems offer targeted delivery, potentially enhancing efficacy and reducing side effects.
- pH variations are increasingly recognized for their diagnostic utility.
Conclusions:
- pH-sensitive DDS represent a significant advancement in targeted therapeutics.
- Further research and development hold potential for broader clinical applications.
- The integration of pH-responsive materials is key to future drug delivery innovations.
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