Iranian Multi-center Osteoporosis Study (IMOS), 2021-2022: the study protocol

Area of Science:

• Gerontology and Geriatric Medicine
• Public Health and Epidemiology
• Musculoskeletal Health

Background:

• The 4th round of the Iranian Multi-center Osteoporosis Study (IMOS) protocol is presented.
• Osteoporosis and sarcopenia are significant public health concerns, particularly in aging populations.
• Understanding their prevalence and risk factors is crucial for effective health interventions.

Purpose of the Study:

• To estimate the national prevalence of osteoporosis and sarcopenia in Iranian adults aged 50 years and older.
• To identify key risk factors associated with these conditions in both urban and rural populations.
• To provide data for health system evaluation and policymaking regarding musculoskeletal health.

Main Methods:

• A multi-stage random sampling method was employed across 31 Iranian provinces.
• A sample of 2530 individuals aged 50+ was recruited from the STEPs-2021 survey.
• Bone mineral density, muscle mass, fat mass (DXA), and Trabecular Bone Score (TBS) were measured; anthropometric, physical, and interview data were collected; laboratory tests were conducted.

Main Results:

• Data analysis is pending, but the study is designed to yield national prevalence estimates for osteoporosis and sarcopenia.
• The protocol accounts for sampling design, non-response, and post-stratification weights for accurate estimations.
• Expected results will detail the prevalence and determinants of these conditions.

Conclusions:

• The IMOS study protocol is established to provide crucial national data on osteoporosis and sarcopenia.
• Findings will inform public health strategies and policy development for musculoskeletal health in Iran.
• This research will contribute to a better understanding of aging-related bone and muscle health at a national level.