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Ivabradine toxicity: a case report.
Kavisha Singh1, Muthukumar R Alagarraju1, Carl E Wolf2
1Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-8830, USA.
Journal of Medical Case Reports
|October 24, 2022
Summary
This case study highlights ivabradine toxicity causing symptomatic bradycardia. Measuring serum ivabradine levels confirmed the diagnosis, offering insights into drug toxicity management.
Area of Science:
- Cardiology
- Clinical Pharmacology
Background:
- Ivabradine is a medication used to treat heart conditions.
- Symptomatic bradycardia is a significant adverse effect that can occur with certain medications.
Observation:
- A 43-year-old female experienced syncope and dizziness due to a heart rate of 50 bpm.
- She was taking ivabradine for inappropriate sinus tachycardia.
Findings:
- Diagnosis of ivabradine toxicity was made through serum ivabradine level measurement.
- This diagnostic approach is not yet widely clinically available.
Implications:
- Serum ivabradine level measurement can confirm toxicity.
- Understanding ivabradine pharmacokinetics is crucial for diagnosing and managing toxicity.
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