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Updated: Aug 24, 2025

Detecting Amyloid-β Accumulation via Immunofluorescent Staining in a Mouse Model of Alzheimer's Disease
Published on: April 19, 2021
Amyloid-Eszett (Aß), a false positive of amyloid-beta (Aβ)
1Independent Researcher, Ikenobe 3011-2, Kagawa-ken 761-0799, Japan.
Abstract:
When the Greek letter beta (β) is accidentally confused for the German letter Eszett (ß), and replaced by it, this can lead to some unfortunate consequences in science, academic publishing, and thus the accuracy of the academic record. In this letter, I document the existence - due to this substitution - of a false positive of amyloid-beta (Aβ), namely amyloid-Eszett (Aß), which does not exist. In total, 242 false positives were identified in PubMed. Of these, 21 were published in 2022, and these were examined in more detail. Although fundamental findings of papers related to Alzheimer's disease are likely not affected by this error, these papers do carry an error nonetheless.
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