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High FN1 expression correlates with gastric cancer progression
Junliang Li1, Cheng Chen2, Bo Chen3
1The First School of Clinical Medicine of Lanzhou University, Lanzhou, Gansu, China; Department of General Surgical, Gansu Provincial Hospital, Lanzhou, Gansu, China; The First School of Clinical Medical, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.
High epithelial fibronectin 1 (E-FN1) expression in gastric cancer predicts poor survival. Stromal fibronectin 1 (S-FN1) is linked to tumor progression but not directly to survival outcomes.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Gastric cancer's high stromal ratio correlates with poor prognosis.
- Fibronectin 1 (FN1) is a primary component of the gastric cancer stroma.
Purpose of the Study:
- To investigate Fibronectin 1 (FN1) expression patterns in gastric cancer.
- To analyze the relationship between FN1 expression, clinicopathological features, survival, and immune markers.
Main Methods:
- Tissue microarrays constructed from 86 paired gastric cancer and adjacent normal tissues.
- Analysis of epithelial FN1 (E-FN1) and stromal FN1 (S-FN1) expression.
- Statistical analysis including chi-square, log-rank tests, and Cox regression; Spearman correlation for FN1 with MMR and immune checkpoints.
Main Results:
- FN1 predominantly expressed in gastric cancer tissues, mainly in the stroma.
- High E-FN1 expression associated with decreased overall survival (OS).
- High S-FN1 expression correlated with advanced age, higher pathological grade, advanced T/N/TNM stages, and vessel/lymphatic invasion.
Conclusions:
- High E-FN1 expression is a predictor of poor overall survival in gastric cancer.
- S-FN1 expression is associated with gastric cancer progression and clinicopathological severity.
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