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Complement System

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...

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Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

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Complement C1s as a diagnostic marker and therapeutic target: Progress and propective.

Jun Ye^1,2, Peng Yang³, Yili Yang⁴

¹Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, China.

Frontiers in Immunology

|October 24, 2022

Summary

The complement system

Keywords:

C1s biomarker complement immunity protein

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Area of Science:

Immunology
Molecular Biology
Biochemistry

Background:

The complement system links innate and adaptive immunity, maintaining homeostasis.
The C1 complex initiates the classical complement pathway.
C1s deficiency and gain-of-function variants are linked to autoimmune diseases and genetic disorders.

Purpose of the Study:

To review the biological properties of C1s.
To explore C1s's role in disease development and diagnosis.
To summarize advancements in C1s-targeting drug development.

Main Methods:

Literature review of C1s's biological functions.
Analysis of C1s's association with various diseases.
Survey of therapeutic strategies targeting C1s.

Main Results:

C1s is implicated in inflammation, autoimmunity, and cancer.
C1s serves as a potential diagnostic biomarker.
Therapeutic agents targeting C1s show promise, with one antibody approved for cold agglutinin disease.

Conclusions:

C1s is a crucial molecule in immune responses and homeostasis.
C1s is a valuable biomarker for disease diagnosis and monitoring.
Targeting C1s represents a promising therapeutic strategy for various conditions.