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Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
Published on: April 12, 2024
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Immunotherapy improves disease prognosis by affecting the tumor microenvironment: A bibliometric study
Xin Wu1, Zhen Deng2, Qiangqiang Zhao3
1Department of Spine Surgery, Third Xiangya Hospital, Central South University, Changsha, China.
Frontiers in Immunology
|October 24, 2022
Summary
This bibliometric analysis reveals key trends in immunotherapy-tumor microenvironment (TME) research, highlighting collaborations and emerging topics like nanomedicine and m6A modification for improved cancer treatment strategies.
Area of Science:
- Oncology and Immunology research
- Bibliometric analysis of scientific literature
- Tumor microenvironment (TME) and immunotherapy interactions
Background:
- Immunotherapy shows promise for cancer treatment, intricately linked to the tumor microenvironment.
- Understanding TME-immunotherapy relationships is crucial for advancing cancer therapies.
- This study maps the knowledge landscape of immunotherapy-TME research.
Approach:
- Bibliometric and visual methods were employed for a comprehensive overview.
- Data was retrieved from the Web of Science Core Collection (WoSCC).
- VOSviewer and Citespace software facilitated literature measurement and knowledge graph analysis.
Key Points:
- Analysis of 1,419 journals, 53,773 authors, 7,008 institutions, and 92 countries/regions.
- Key research areas include TME elements, immunotherapy foundations, and cancer applications.
- Emerging hotspots: drug resistance, prognosis prediction, efficacy prediction, and m6A modification.
Conclusions:
- Nanomedicine and m6A modification are identified as future research hot topics.
- Prognosis prediction using bioinformatics presents another significant future research avenue.
- Future work should explore m6A's role in tumor development and TME modulation for enhanced immunotherapy response.
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