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Natural cell based biomimetic cellular transformers for targeted therapy of digestive system cancer
Xiaomeng Tang1, Dan Li1, Yongwei Gu1
1Department of Pharmacy, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Abstract:
Digestive system cancer is the most common cause of cancer death in the world. Although cancer treatment options are increasingly diversified, the mortality rate of malignant cancer of the digestive system remains high. Therefore, it is necessary to explore effective cancer treatment methods. Recently, biomimetic nanoparticle delivery systems based on natural cells that organically integrate the low immunogenicity, high biocompatibility, cancer targeting, and controllable, versatile functionality of smart nanocarrier design with natural cells have been expected to break through the bottleneck of tumor targeted therapy. In this review, we focus on the dynamic changes and complex cellular communications that occur in vivo in natural cells based vehicles. Recent studies on the development of advanced targeted drug delivery systems using the dynamic behaviors such as specific surface protein affinity, morphological changes, and phenotypic polarization of natural cells are summarized. In addition to drug delivery mediated by dynamic behavior, functional "delivery" based on the natural cell themselves is also involved. Aiming to make the best use of the functions of cells, providing clues for the development of advanced drug delivery platforms.
Insights
Biomimetic nanoparticle delivery systems using natural cells offer a promising approach to overcome limitations in digestive system cancer treatment. These systems leverage cellular dynamics for enhanced tumor targeting and drug delivery.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Digestive system cancer remains a leading cause of cancer mortality globally.
- Current cancer treatment options have limitations in effectively reducing mortality rates.
- Targeted therapy for tumors faces challenges that need innovative solutions.
Purpose of the Study:
- To review recent advancements in biomimetic nanoparticle delivery systems for cancer therapy.
- To explore the utilization of natural cells in developing smart nanocarrier systems.
- To highlight the potential of these systems in overcoming tumor-targeted therapy bottlenecks.
Main Methods:
- Focus on dynamic changes and cellular communications of natural cell-based vehicles in vivo.
- Summarize studies on advanced targeted drug delivery systems utilizing natural cell behaviors (e.g., surface protein affinity, morphological changes, phenotypic polarization).
- Include functional delivery mechanisms inherent to the natural cells themselves.
Main Results:
- Biomimetic systems integrate low immunogenicity and high biocompatibility with smart nanocarrier functionalities.
- Natural cell-based vehicles demonstrate controllable and versatile functions for cancer targeting.
- Dynamic behaviors of natural cells are effectively harnessed for targeted drug delivery.
Conclusions:
- Biomimetic nanoparticle delivery systems show significant promise for improving digestive system cancer treatment.
- Leveraging natural cell dynamics offers a novel strategy for advanced drug delivery platforms.
- Further development in this area could lead to breakthroughs in tumor-targeted therapy.
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