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Surface-based functional metrics and auditory cortex characteristics in chronic tinnitus.

Xiaoyan Ma1,2,3,4,5,6, Ningxuan Chen7,8,9,10,11, Fangyuan Wang2,3,4,5,6

  • 1The First Affiliated Hospital of Xi'an, Jiaotong University, Shanxi, China.

Heliyon
|October 24, 2022
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Summary

Abnormal auditory cortex (AC) activity may cause tinnitus. This study found reduced AC volume and surface area, along with increased regional homogeneity in tinnitus patients, suggesting structural and functional brain changes.

Keywords:
Resting-state fMRISecondary auditory cortexTinnitus

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Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Medical Imaging

Background:

  • Abnormal auditory cortex (AC) neuronal activity is hypothesized to underlie tinnitus.
  • Tinnitus is a common auditory disturbance affecting many individuals.
  • Understanding AC alterations is crucial for tinnitus research.

Purpose of the Study:

  • To investigate auditory cortex (AC) structural and functional differences in chronic tinnitus patients.
  • To evaluate AC volume, curvature, surface area, thickness, and functional metrics.
  • To correlate AC characteristics with tinnitus severity.

Main Methods:

  • Magnetic resonance imaging (MRI) was used to scan 63 tinnitus patients and 36 healthy controls (HC).
  • DPABISurf software computed AC structural and surface-based functional metrics.
  • Tinnitus severity was assessed using THI, THQ, and VAS questionnaires.

Main Results:

  • Tinnitus patients showed increased regional homogeneity (ReHo) in the right secondary AC compared to HC.
  • Significant reductions in right secondary AC volume and surface area were observed in tinnitus patients.
  • Negative correlations were found between tinnitus pitch and right secondary AC volume/area.

Conclusions:

  • The findings suggest that structural and functional abnormalities in the right secondary auditory cortex are associated with chronic tinnitus.
  • These AC alterations may contribute to the perception of tinnitus.
  • Further research into AC's role in tinnitus is warranted.