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Nutritional status and function after high-calorie formula vs. Chinese food intervention in undernourished children
Yiting Zhao1,2, Lu He1, Tingting Peng1
1Department of Rehabilitation, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Insights
High-calorie formula improved nutritional status and motor function in children with cerebral palsy (CP). This intervention offers a safe and effective option for undernourished children with CP.
Area of Science:
- Pediatric Nutrition
- Neurology
- Clinical Trials
Background:
- Undernutrition and motor dysfunction are common in children with cerebral palsy (CP).
- Optimizing nutritional status is crucial for improving motor function in these children.
Purpose of the Study:
- To compare the efficacy and safety of high-calorie formula versus traditional Chinese food for improving nutritional status and gross motor function in undernourished children with CP.
Main Methods:
- A 6-month randomized controlled trial involving 110 children (1-10 years) with CP and undernutrition.
- Participants were assigned to a high-calorie formula or a Chinese daily food diet group.
- Nutritional status (weight, height, z-scores) and gross motor function (Gross Motor Function Measure - GMFM) were assessed at baseline and follow-up.
Main Results:
- Both groups showed significant improvements in weight, height, z-scores, and GMFM (p < 0.05).
- The high-calorie formula group demonstrated significantly greater improvements in weight, weight-for-age z-scores, and GMFM compared to the control group (p < 0.05).
- Adverse events were mild and comparable between groups.
Conclusions:
- High-calorie formula intervention is effective and safe for improving nutritional status and gross motor function in undernourished children with CP.
- This approach offers a promising strategy for managing undernutrition and associated motor deficits in pediatric CP.
Aim:
To investigate the efficacy and safety of high-calorie formula vs. Chinese daily food on the nutritional status and motor function of undernourished children with cerebral palsy (CP).
Methods:
In this prospective, assessor-blind, and randomized controlled trial, we recruited children (1-10 years) with CP and undernutrition based on the WHO and the American Society for Parenteral and Enteral Nutrition criteria from the National Children's Medical Center. Participants were randomly allocated (1:1) to a high-calorie formula group or a Chinese daily food diet group (control group) for 6 months. Indirect calorimetry was used to estimate energy requirements. We compared the nutritional status and gross motor function of participants in both groups based on weight, height, z-scores (weight-for-age, height-for-age, weight-for-height, and BMI-for-age), and the Gross Motor Function Measure (GMFM), respectively, at baseline, 3-, and 6-months follow-up. In addition, the effective rate of nutritional intervention, and adverse events were simultaneously assessed.
Results:
From July 2020 to December 2021, a total of 119 participants were enrolled and randomized, and 110 participants completed the study (with 54 children in the high-calorie formula group and 56 children in the control group). After 6 months of treatment, the weight, height, z-scores (weight-for-height, weight-for-age, and BMI-for-age), and GMFM of both groups were significantly improved (p < 0.05). There were significant differences in changes in weight, weight-for-age z-scores, and GMFM between the two groups (p < 0.05). During the study period, 16 children experienced at least one mild adverse event [9 (16.7%) in the formula group and 7 (12.5%) in the control group].
Conclusion:
Nutritional intervention with a high-calorie formula may be an effective and safe option in children with CP for improving undernutrition and gross motor dysfunction.
Clinical Trial Registration:
www.chictr.org.cn, identifier: ChiCTR2000033878.
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