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Ion channels as a therapeutic target for renal fibrosis

Peng Yan1, Ben Ke1, Xiangdong Fang1

  • 1Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Frontiers in Physiology
|October 24, 2022
PubMed

Insights

Renal ion channels are crucial in kidney fibrosis. Understanding their transport and signaling pathways offers new therapeutic targets for chronic kidney disease.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Physiology

Background:

  • Renal ion channel dysfunction contributes to kidney disease progression and fibrosis.
  • Effective treatments for renal fibrosis are limited, necessitating novel therapeutic strategies.
  • Ion channels are integral to renal electrolyte balance and cellular signaling.

Purpose of the Study:

  • To review the role of various ion channels in renal fibrosis.
  • To elucidate the signaling pathways and mechanisms involving ion channels in kidney fibrosis.
  • To identify potential therapeutic targets for mitigating renal fibrosis.

Main Methods:

  • Literature review of studies on ion channels and renal fibrosis.
  • Analysis of signaling pathways mediated by chloride, calcium, and sodium channels.
  • Examination of the contribution of potassium channels to renal fibrosis.

Main Results:

  • Cystic fibrosis transmembrane conductance regulator (CFTR) and transmembrane Member 16A (TMEM16A) chloride channels influence renal fibrosis.
  • Calcium (Ca2+) handling channels, including CRAC, purinergic receptors, and TRP channels, are implicated in fibrosis.
  • Sodium (Na+) transport channels (ENaC, Na+, K+-ATPase, Na+-H+ exchangers) and potassium (K+) channels also play significant roles.

Conclusions:

  • Dissecting ion channel mechanisms in renal fibrosis can reveal new therapeutic avenues.
  • Targeting specific ion channels may offer strategies to slow renal fibrosis progression.
  • Further research into these channels could lead to novel treatments for chronic kidney disease.
Keywords:
Ca2+ signalingCl− channelsK+ channelsNa+ transportion channelskidneyrenal fibrosis

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