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Druggable targets and therapeutic development for COVID-19

Xiaohua Duan1, Lauretta A Lacko1, Shuibing Chen1

  • 1Department of Surgery, Weill Cornell Medicine, New York, NY, United States.

Frontiers in Chemistry
|October 24, 2022
PubMed

Insights

This study explores therapeutic targets for COVID-19 by examining SARS-CoV-2 proteins and host factors. It reviews current and investigational treatments for coronavirus disease.

Area of Science:

  • Virology
  • Immunology
  • Pharmacology

Background:

  • Coronavirus disease (COVID-19), caused by SARS-CoV-2, presents significant global health and economic challenges.
  • Limited therapeutic options necessitate deeper understanding of viral biology and host interactions.
  • SARS-CoV-2 proteins are crucial for its life cycle, making them potential drug targets.

Purpose of the Study:

  • To discuss the medicinal value of essential SARS-CoV-2 proteins and key host factors.
  • To review current therapeutic interventions for COVID-19 patients.
  • To highlight potential targets for novel COVID-19 treatments.

Main Methods:

  • Review of scientific literature on SARS-CoV-2 proteins and host interactions.
  • Analysis of viral life cycle mechanisms.
  • Summary of clinical trial data for COVID-19 therapeutics.

Main Results:

  • SARS-CoV-2 proteins and host factors are identified as critical for viral replication and pathogenesis.
  • A range of therapeutic strategies targeting viral and host components are under investigation.
  • Approved and experimental treatments show varying efficacy.

Conclusions:

  • Targeting SARS-CoV-2 proteins and host factors offers promising avenues for COVID-19 treatment.
  • Continued research into viral-host interactions is vital for developing effective therapies.
  • Comprehensive review of interventions aids clinical decision-making and future drug development.
Keywords:
RNA-dependent RNA polymeraseSARS-CoV-2host factorsmain proteaseneutralizing antibodiespapain-like protease

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