Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cirrhosis I: Introduction

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Genotypes of Hepatitis B and D Viruses Among Patients With Hepatitis D in the United States.

Journal of viral hepatitis·2026

Same author

Telomere biology disorders and hepatic disease.

Seminars in hematology·2026

Same author

Automated Delineation of Couinaud Segments at CT for Future Liver Remnant Volumetry.

Radiology. Artificial intelligence·2026

Same author

Hepatic Manifestations and Response to Treatment in Deficiency of Adenosine Deaminase 2.

Liver international : official journal of the International Association for the Study of the Liver·2026

Same author

Association of Changes in Portal Insulin with Immunometabolism During and After Hepatitis C Virus Infection.

Journal of clinical and translational hepatology·2026

Same author

Portal Vein Tryptophan Pathway Analysis Reveals Gut-Mediated Inflammatory Pathway Predominance in HCV Infection.

Liver international : official journal of the International Association for the Study of the Liver·2026

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

The In ovo CAM-assay as a Xenograft Model for Sarcoma

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

Angiosarcoma in Long-Standing Nodular Regenerative Hyperplasia.

Nehna Abdul Majeed¹, David E Kleiner², Gulbu Uzel³

¹Liver Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.

ACG Case Reports Journal

|October 24, 2022

Summary

Nodular regenerative hyperplasia (NRH) can be linked to malignancy. This case report details a patient with NRH and X-linked agammaglobulinemia who developed hepatic angiosarcoma, highlighting a rare association.

More Related Videos

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Related Experiment Videos

Last Updated: Jul 3, 2026

The In ovo CAM-assay as a Xenograft Model for Sarcoma

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Area of Science:

Hepatology
Oncology
Immunology

Background:

Nodular regenerative hyperplasia (NRH) is a rare liver condition causing noncirrhotic portal hypertension.
X-linked agammaglobulinemia is a primary immunodeficiency disorder.

Observation:

A 29-year-old male with X-linked agammaglobulinemia and NRH presented with pancytopenia and elevated liver enzymes.
Imaging revealed numerous hepatic lesions, and biopsy confirmed hepatic angiosarcoma.

Findings:

The patient had advanced hepatic angiosarcoma and was ineligible for treatment.
Autopsy confirmed widespread angiosarcoma infiltrating the liver.

Implications:

This case suggests a potential association between NRH and the development of malignancy, specifically angiosarcoma.
Further research is warranted to explore the link between NRH, immunodeficiency, and cancer risk.