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Updated: Aug 24, 2025

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
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Function and therapeutic potential of transient receptor potential ankyrin 1 in fibrosis

Yicheng Wei1,2,3, Jialuo Cai3,4, Ruiqiu Zhu2,3

  • 1Third Affiliated Hospital of Shanghai University/Wenzhou People's Hospital, Wenzhou, China.

Frontiers in Pharmacology
|October 24, 2022
PubMed

Insights

Transient receptor potential ankyrin 1 (TRPA1) channels play a key role in fibroblast activation and fibrosis. Targeting TRPA1 shows promise as an adjuvant therapy for treating fibrotic diseases.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Immunology

Background:

  • The Transient Receptor Potential (TRP) superfamily comprises cation channels with diverse cellular functions.
  • TRPA1 (transient receptor potential ankyrin 1) is a TRP channel involved in cellular signaling, particularly calcium influx.
  • Fibroblasts are crucial cells in tissue repair and fibrosis, and their activation is central to fibrotic diseases.

Purpose of the Study:

  • To review the multifaceted role of TRPA1 in fibroblast activation and its implications in fibrosis.
  • To elucidate the interaction between TRPA1 and inflammatory factors in driving fibroblast-mediated fibrosis.
  • To highlight TRPA1 as a potential therapeutic target for managing fibrotic conditions across various organs.

Main Methods:

  • Literature review focusing on studies investigating TRPA1 function in fibroblasts.
  • Analysis of the mechanisms linking TRPA1 activation to inflammatory responses and fibrosis.
  • Examination of existing clinical trial data on TRPA1 as a therapeutic strategy.

Main Results:

  • TRPA1 channels are expressed in fibroblasts and influence their activation state.
  • Interactions between TRPA1 and inflammatory mediators contribute to fibroblast-driven fibrosis.
  • TRPA1 exhibits organ-specific roles in fibrotic processes.

Conclusions:

  • TRPA1 is a significant regulator of fibroblast function in the context of fibrosis.
  • TRPA1 represents a promising therapeutic target for treating inflammatory and immune-mediated fibrotic diseases.
  • Clinical evidence supports TRPA1's potential as an adjuvant therapy for fibrosis.
Keywords:
TGF-βTRPA1TRPA1 antagonistsfibrosisinflammation

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