Related Experiment Video
Updated: Aug 24, 2025
09:40
Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells
Published on: June 20, 2018
17.8K
Targeting ADAM10 in Renal Diseases
1Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325088, China.
Current Molecular Medicine
|October 24, 2022
Summary
ADAM10, a key protein in tissue development, significantly impacts kidney function and disease progression. Targeting ADAM10 offers a promising therapeutic strategy for various renal conditions.
Area of Science:
- Nephrology
- Molecular Biology
- Biochemistry
Background:
- ADAM10 belongs to the ADAM superfamily, characterized by cell surface proteins with adhesion and protease domains.
- Its crucial roles in tissue development and disease pathogenesis are increasingly recognized.
- This review focuses on ADAM10's specific functions in kidney development and its association with renal diseases.
Approach:
- This review synthesizes current research on ADAM10's function in the kidney.
- It examines the catalytic mechanisms of ADAM10 on key kidney-related molecules.
- The review correlates ADAM10 activity with the pathogenesis of various renal diseases.
Key Points:
- ADAM10 modulates critical kidney-related molecules including Notch, EGF receptors, TNF-α, CXCL16, E-cadherin, CDO1, meprin, and klotho.
- The proteinase activity of ADAM10 is integral to its diverse biological functions.
- Dysregulation of ADAM10 is implicated in glomerular diseases, acute kidney injury, and renal fibrosis.
Conclusions:
- ADAM10 plays a vital role in kidney development and homeostasis.
- Its involvement in renal disease pathogenesis suggests it as a potential therapeutic target.
- Further investigation into ADAM10 modulation could lead to novel treatments for kidney disorders.
Related Concept Videos
01:25Antihypertensive Drugs: Direct Renin Inhibitors
767
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
767
01:28Chronic Kidney Disease III: Interprofessional Care
70
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
70
01:28Renal Drug Excretion: Tubular Secretion
259
Active tubular secretion is a robust, energy-demanding process that utilizes carrier systems to transport drugs into renal tubules. The active renal secretion systems include the organic anion transporter (OAT) for weak acids and the organic cation transporter (OCT) for weak bases. Structurally similar drugs can compete for the same transporter, potentially leading to drug accumulation and toxicity. However, this principle can be exploited therapeutically. One example is probenecid (Probalan),...
259
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
487
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
487
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
53
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
53
01:20Renal Corpuscle
3.1K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
3.1K