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Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine
Ahmad Reza Farmani1,2,3, Mohammad Ali Salmeh4, Zahra Golkar5
1Tissue Engineering and Applied Cell Sciences Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran 14166-34793, Iran.
Journal of Functional Biomaterials
|October 24, 2022
Summary
Lithium-doped bioceramics show promise for tissue regeneration and cancer treatment due to their biocompatibility and multifunctionality. These advanced biomaterials offer significant potential for diverse clinical applications in tissue engineering and beyond.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Biomedical Engineering
Background:
- Lithium (Li) possesses diverse therapeutic properties, including applications in treating bipolar disorder, and exhibiting antibacterial, anticancer, antiviral, and pro-regenerative effects.
- Lithium can be integrated into biomaterials via Li chloride/carbonate in polymers or doping in bioceramics.
- Li-doped bioceramics offer biocompatibility and multifunctionality, presenting opportunities for biomedical research and clinical use.
Purpose of the Study:
- To explore the potential of lithium-doped bioceramics in various biomedical applications.
- To highlight the role of lithium in immunomodulation, regeneration, and cancer therapy.
- To investigate the combination of Li-doped bioceramics with polymers for advanced biomaterials and 3D printing applications.
Main Methods:
- Incorporation of lithium into bioceramic structures.
- Fabrication of lithium-doped bioceramic/polymer composites.
- Evaluation of biocompatibility and therapeutic effects (regenerative, anticancer, antiviral).
Main Results:
- Li-doped bioceramics demonstrate immunomodulatory capabilities beneficial for bone, tooth, cartilage, and nerve regeneration, as well as osteochondral repair and wound healing.
- Lithium's synergistic effects with anticancer drugs and its inherent anticancer properties suggest potential in cancer treatments.
- The role of lithium in autophagy may underpin its regenerative, antiviral, and anticancer activities.
- Combining Li-doped bioceramics with polymers yields flexible biomaterials suitable for 3D printing in tissue engineering.
Conclusions:
- Li-doped bioceramics are versatile biomaterials with significant potential for tissue regeneration and cancer therapy.
- The integration of lithium into bioceramics enhances their therapeutic and regenerative properties.
- These advanced materials hold considerable promise for future clinical applications in tissue engineering and regenerative medicine.
