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Zinc-Based Biodegradable Materials for Orthopaedic Internal Fixation.

Yang Liu1, Tianming Du1, Aike Qiao1

  • 1Department of Biomedical Engineering, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China.

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|October 24, 2022
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Summary

Zinc-based alloys offer a promising alternative to traditional internal fixation materials, addressing complications and secondary surgeries. Their moderate degradation rate and mechanical properties make them ideal for orthopedic fracture fixation.

Keywords:
Zinc-based biodegradable materialsbiocompatibilitybiodegradabilitymechanical propertyorthopedic implant

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Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Materials Engineering

Background:

  • Traditional internal fixation materials often lead to complications and necessitate secondary surgeries.
  • Biodegradable alloys like magnesium (Mg), iron (Fe), and zinc (Zn) present alternatives to inert materials.
  • Mg-based alloys show promise but face challenges with rapid degradation and hydrogen release.

Purpose of the Study:

  • To review the research progress of zinc (Zn)-based biodegradable materials for orthopedic internal fixation.
  • To explore the potential of Zn alloys as alternatives to traditional fixation materials.
  • To provide a reference for future studies on Zn-based biodegradable materials in orthopedics.

Main Methods:

  • Review of existing in vitro and in vivo studies on Zn-based alloys and composites.
  • Analysis of biodegradability, mechanical properties, and biocompatibility of Zn-based materials.
  • Comparison of Zn alloys with traditional materials like titanium (Ti).

Main Results:

  • Zn alloys exhibit mechanical properties comparable to titanium (Ti).
  • Zn alloys demonstrate a moderate degradation rate, suitable for load-bearing skeletal sites.
  • Emerging Zn-based alloys and composites show potential for clinical application in fracture fixation.

Conclusions:

  • Zn-based biodegradable materials are a viable alternative for internal fixation, potentially reducing complications.
  • Further research on Zn-based materials is crucial for their successful clinical application in orthopedic fracture fixation.
  • Zn alloys offer a promising pathway towards improved patient outcomes in orthopedic surgery.